Dr. Julian Lombard wins 2014 Eugene M. Landis Research Award
July 15, 2013 College News - Julian H. Lombard, PhD, Professor of Physiology, has been named the 2014 recipient of the Eugene M. Landis Research Award, established by the Microcirculatory Society in 1969 to recognize an outstanding investigator in the field of microcirculation.
Dr. Lombard’s research focuses on the mechanisms behind vascular control in salt-sensitive hypertension, the role of oxygen in blood vessel constriction in hypertension, and vascular abnormalities associated with high levels of salt in the diet. Recently, his team discovered that high salt diet leads to severe dysfunctional changes in blood vessels even in the absence of an elevated blood pressure.
In humans, dysfunctional changes in blood vessels similar to those observed in animals fed high salt diet have been shown to be associated with a variety of adverse cardiovascular outcomes including stroke, heart attack, the development of hypertension, and sudden cardiovascular death. A major goal of Dr. Lombard’s work is to determine the mechanisms by which elevated dietary salt intake leads to abnormal blood vessel function even before the development of hypertension.
Dr. Lombard earned his undergraduate degree in biological sciences at the University of Texas – El Paso, in 1969. He received his master of science in zoology and physiology from Arizona State University in 1971, and then earned his PhD from the Medical College of Wisconsin in physiology in 1974. After completing postdoctoral work at the University of Virginia School of Medicine, in 1977, he joined the MCW faculty.
A nationally respected researcher in his field, Dr. Lombard has been continually funded by the National Institutes of Health for more than 30 years. He has published more than 100 papers and book chapters, and has mentored dozens of graduate students. He has served on NIH study sections and has edited numerous peer-reviewed journals.
Dr. Lombard will receive the award at the Society’s annual meeting in 2014.
Mingyu Liang receives prestigious award for novel and exceptional work on the mechanisms behind hypertension and kidney disease
SAN DIEGO—High blood pressure, or hypertension, is a major problem worldwide, with the latest estimates suggesting that a billion people across the globe may have this condition. Hypertension not only takes an enormous cost on health and wellbeing, but it also exacts an expensive financial toll. Complications from this condition including kidney disease, and its resulting treatments, such as long-term dialysis and kidney transplant, are some of the costliest conditions the American health care system must contend with.
Mingyu Liang, M.B., Ph.D., has devoted his career to gaining a better understanding of hypertension and its complications, with the goal of eventually developing new ways to treat this burdensome condition. At the heart of his research are short snippets of RNA, called microRNA (miRNA). These bits of nucleic acid, which control the production of proteins throughout cells, could hold the key to checking hypertension in vulnerable individuals.
For this novel research, the American Physiological Society (APS; www.the-APS.org) has recognized the importance of Dr. Liang’s work by awarding him the Henry Pickering Bowditch Lecture Award. The award is one of the highest offered by the society and is given to scientists younger than 42 years of age whose accomplishments are original and outstanding.
From Mouse to Man
MiRNA was discovered more than 20 years ago, explains Dr. Liang, but its importance for research and therapies for a variety of health conditions has been recognized only recently. Unlike most other types of RNA, miRNA isn’t directly involved in the production of proteins. Rather, these tiny pieces of RNA, averaging 22 units long, regulate the expression of protein-coding genes. They do this primarily by interfering with RNA that’s used for creating proteins.
Liang, who has studied aspects of hypertension and kidney disease since receiving his M.B. degree from Shanghai Medical University in 1994, became interested in miRNA just over a decade later. At the time, he says, little was known about the role of miRNA in physiology or disease.
Using animal models of salt-sensitive hypertension, the most common variety of hypertension in humans, Liang has made significant headway in identifying miRNAs that play an important role in influencing the course of hypertension and the resulting kidney disease. After identifying miRNAs of interest in these animals, Liang uses this information as a basis for molecular, cellular, and genetic studies. Taking what he learns from these animal and cellular models, his work culminates in studies on human subjects.
“Our lab runs the full spectrum from very basic cell biology to human subjects,” Liang says.
A Big Picture View
Like many researchers, Liang has devoted much of his career to studying individual pieces of miRNA or individual genes. In parallel, however, his work has always embraced a systems approach, seeking to grasp how all the components that contribute to hypertension connect to and cause this condition.
“Studying a single gene or single molecule can be very productive,” explains Liang, “but then we always wonder how these bits and pieces fit together. Now we have a lot more tools to allow us to look at whole organs and whole bodies at a deeper level than investigators did years ago. For a complex disease like hypertension, a single gene or molecular mechanism isn’t going to be enough to explain it. We’re going to have to look for the bigger picture.”
Consequently, part of Liang’s work focuses on studying the interconnected molecular networks involved in hypertension and kidney disease. This topic will be a key part of his Bowditch lecture, entitled, “MicroRNAs and Systems Molecular Medicine.”
About the Bowditch Lecture Award
The Henry Pickering Bowditch Lecture Award is named in honor of the first president of the American Physiological Society. By tradition, the Bowditch Lecturer, who is to be younger than 42 years of age, has been named by the president of the Society for their outstanding work in the field. The Award has been given annually since 1956.
About the American Physiological Society (APS)
The American Physiological Society (APS) is a nonprofit organization devoted to fostering education, scientific research, and dissemination of information in the physiological sciences. The Society was founded in 1887 and today has more than 10,500 members. APS publishes 13 scholarly, peer-reviewed journals covering specialized aspects of physiology.