Hartmut Weiler, Ph.D.
Assistant Professor
Phone: (414) 937-3813
Email: hweiler@bcsew.edu
Our laboratory is interested in the role and function of natural pathways that regulate the activity of the plasma coagulation system in embryonic development, in the control of hemostasis and vascular function, and in the host-defense against bacterial infection. Research highlights include:
(1) Demonstration that the protein C pathway fulfils an essential role in placental development, and thereby for pregnancy outcome (ref. 1, 4, 5);
(2) Development of mouse models to study regulation of coagulation and the pathogenesis of thrombosis (ref. 3, 4).
(3) The demonstration that the most common pro-thrombotic mutation in humans (the fV Leiden polymorphism) protects against sepsis. This finding might explain the extraordinarily high prevalence of this mutation in the general population, and points to alternate therapeutic approaches in the treatment and prevention of sepsis (ref. 3).
Technical resources provided by our laboratory include expertise in the generation of transgenic and knockout mice (ref. 6). This resource is available through services provided by the Transgenic Core Facility, directed by Dr. Weiler.
Recent Publications:
Isermann BH, Sood R, Pawlinski R, Zogg M, Kalloway S, Degen JL, Mackman N, Weiler H. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat. Med. 2003; 9:331-337.
Kerlin BA, Yan SB, Isermann BH, Brandt JT, Sood R, Basson BR, Joyce DE, Weiler H, Dhainaut F. Plenary paper: Survival advantage associated with heterozygous Factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia. Blood. 2003; 102:3085-3092.
Kerlin BA, Cooley BC, Isermann BH, Hernandez I, Sood R, Zogg M, Hendrickson SB, Mosesson MW, Lord ST, Weiler H. Cause-effect relation between hyperfibrinogenemia and vascular disease. Blood 2004;103:1728-1734.
Palumbo JS, Zogg M, Talmage KE, Degen JL, Weiler H, Isermann B. Role of fibrinogen- and platelet-mediated hemostasis in mouse embryogenesis and reproduction. J Thromb Haemost. 2004; 2:1368-1379.
Weiler H. Mouse models of thrombosis: thrombomodulin. Thromb Haemost. 2004; 92:467-477.
Miano JM, Ramanan N, Georger MA, de Mesy-Bentley KL, Emerson RL, Balza RO, Xiao Q, Weiler H, Ginty DD and Misra RP. Restricted inactivation of serum response factor to the cardiovascular system. Proc Natl Acad Sci USA 2004; 101:17132-17137.
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