Andrew K. Tryba, Ph.D.
Phone: (414) 456-4975
Ph.D. Biology, Case Western Reserve University, 2000
M.Sc. Biology, Duquesne University, 1993
B.Sc., Zoology, Texas Tech University, 1991
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In my new lab in the Department of Physiology at the Medical College of Wisconsin, we are studying neural networks, cellular and ionic mechanisms underlying respiratory rhythm generation in mammals. This rhythmic activity is necessary for breathing and essential to sustain life. For these studies, we use brain slice preparations from wild type and mutant mice to understand rhythmic activity during normal breathing as well as irregular breathing patterns in Rett Syndrome, SIDS and sleep apnea. We also study another rhythm: cortical rhythmic activity underlying human pediatric epilepsy in which we use cortical tissue removed from patients with intractable epilepsy. This translational research has been instrumental in helping several young patients with seizures and revealed new insights in our understanding of pediatric epilepsy.
Ben-Mabrouk F, Amos LB, Tryba AK., Metabotropic glutamate receptors (mGluR5) activate transient receptor potential canonical channels to improve the regularity of the respiratory rhythm generated by the pre-Bötzinger complex in mice. Eur J Neurosci. 2012 May 22. doi: 10.1111/j.1460-9568.2012.08091.x. [Epub ahead of print]
Rhythmic intrinsic bursting neurons in human neocortex obtained from pediatric patients with epilepsy.
Tryba AK, Kaczorowski CC, Ben-Mabrouk F, Elsen FP, Lew SM, Marcuccilli CJ. Eur J Neurosci. 2011 Jul;34(1):31-44. doi: 10.1111/j.1460-9568.2011.07746.x. PMID: 21722205
Marcuccilli CJ, Tryba AK, van Drongelen W, Koch H, Viemari JC, Peña-Ortega F, Doren EL, Pytel P, Chevalier M, Mrejeru A, Kohrman MH, Lasky RE, Lew SM, Frim DM, Ramirez JM., Neuronal Bursting Properties in Focal and Parafocal Regions in Pediatric Neocortical Epilepsy Stratified by Histology. J Clin Neurophysiol. 2010 Oct 29. [Epub ahead of print]PMID: 21076335 [PubMed - as supplied by publisher
Ben-Mabrouk F. and Tryba A.K. Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity. Eur J Neurosci. 31(7):1219-32. PMID: 20345918
Viemari JC, Tryba AK. Bioaminergic neuromodulation of respiratory rhythm in vitro. Respir Physiol Neurobiol. 2009 PMID: 19538922
Chevalier M, Ben-Mabrouk F, Tryba AK. Background sodium current underlying respiratory rhythm regularity.
Eur J Neurosci. 2008 Dec;28(12):2423-33. Epub 2008 Nov 21.
Tryba AK, Pena F, Lieske SP, Viemari JC, Thoby-Brisson M, Ramirez JM. Differential modulation of neural network and pacemaker activity underlying eupnea and sigh breathing activities. J Neurophysiol. 2008 Feb 20
Tryba AK, Peña F and Ramirez JM (2006) Gasping activity in vitro: a rhythmic behavior dependent on 5HT2A receptors. J. Neuroscience; 26(10):2623-2634.
Selected as “Recommended Reading” by Faculty of 1000
Featured in Milwaukee Journal Sentinel, “Research team makes key finding in battling SIDS” (2006), http://www.jsonline.com/story/index.aspx?id=410545
Viemari JC, Roux JC, Tryba AK, Saywell V, Burnet H, Pena F, Zanella S, Bevengut M, Barthelemy-Requin M, Herzing LB, Moncla A, Mancini J, Ramirez JM, Villard L, Hilaire G. Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice. J Neurosci 25(10): 115210-11530, 2005.
Ramirez JM, Tryba AK, Peña F. Pacemaker Neurons and Neural Networks: An Integrative View. Curr Opin Neurobiology. 14:1-10. 2004.
Peña F, Parkis MA, Tryba AK, Ramirez JM. Differential contribution of pacemaker properties to the generation of respiratory rhythms during normoxia and hypoxia. Neuron. 43(1):105-117, 2004. Selected as a "Must Read" by Faculty of 1000.
Tryba AK and Ramirez JM. Hyperthermia modulates respiratory pacemaker bursting properties. J Neurophysiol. 92:2844-2852, 2004.
Tryba AK and Ramirez JM. Background sodium current stabilizes bursting in respiratory pacemaker neurons. J Neurobiol. 60(4):481-489, 2004.
Tryba AK, Peña F and Ramirez JM. Stabilization of bursting in respiratory pacemaker neurons. J Neurosci. 23(8):3538, 2003.
Tryba AK and Ramirez JM. Response of the respiratory network of mice to hyperthermia. J Neurophysiol. 89:2975-2983, 2003.