FACULTY LIST
 Richard J. Roman, Ph.D.
Professor and Director, Kidney Research Center
Phone: (414) 456-8723
Email: rroman@mcw.edu
B.S. Chemical Engineering, Rutgers University, 1973
Ph.D. Pharmacology, University of Tennessee, 1977
Postdoctoral Fellow, Harvard Medical School, 1981
Our lab focuses on the role of P450 eicosanoids in the control of renal tubular transport and vascular function and the molecular genetics of hypertension. The techniques we utilize include, micropuncture and isolated perfused tubule studies of single nephron function, studies in isolated perfused vessels, patch clamp studies of Ca and K channel activity in smooth muscle, biochemical analysis of eicosanoids, IP3, PKC, DAG and other signaling molecules, Northern and Western blots, PCR molecular cloning, DNA sequencing, transient expression studies in cultured cells, and in vivo. We also use genetic mapping expression profiling and physiologic profiling to search for genes contributing to the development of hypertension, glomerulosclerosis and diabetes.
Recent Publications:
Miyata N, Seki T, Tanaka Y, Omura T, Taniguchi K, Doi M, Bandou K, Kametani S, Sato M, Okuyama S, Cambj-Sapunar L, Harder DR, Roman RJ. Beneficial Effects of a new 20-HETE Synthesis Inhibitor, TS-011,on Hemorrhagic and Ischemic Stroke. J Pharmacol Exp Ther. 2005 Jul;90(4) 607-12; [Epub Apr 2005].
Rangel-Filho A, Sharma M, Datta YH, Moreno C, Roman RJ, Iwamoto Y, Provoost AP, Lazar J, Jacob HJ. RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. J Am Soc Nephrol. 2005 Apr;16(4):852-6.
Dahly-Vernon AJ, Sharma M, McCarthy ET, Savin VJ, Ledbetter SR, Roman RJ. Transforming growth factor-beta, 20-HETE interaction, and glomerular injury in Dahl salt-sensitive rats. Hypertension. 2005 Apr;45(4):643-8.
Vera T, Taylor M, Bohman Q, Flasch A, Roman RJ, Stec DE. Fenofibrate prevents the development of angiotensin II-dependent hypertension in mice. Hypertension. 2005 Apr;45(4):730-5.
Chen P, Guo M, Wygle D, Edwards PA, Falck JR, Roman RJ, Scicli AG. Inhibitors of cytochrome P450 4A suppress angiogenic responses. Am J Pathol. 2005 Feb;166(2):615-24.
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