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Carol Moreno Quinn, M.D., Ph.D.
Assistant Professor
Phone: (414) 955-4475 
Email: quinn@mcw.edu
M.D. Universidad de Murcia, Murcia, Spain, 1995
Ph.D. Universidad de Murcia, Murcia, Spain, 1999
Postdoctoral Fellow Physiology and Genomics, Medical College of Wisconsin, 2004
Research areas: Cardiovascular Physiology
  Renal Physiology
  Genetics & Genomics

Complex diseases such as hypertension and renal failure are determined by the interaction of multiple genes with environmental factors.  My research interest is focused on identification of the genetic determinants of hypertension and renal disease in rat models of hypertension. Our main strategy is to identify chromosomal regions containing the causative genes through linkage analysis in segregating populations of rats. By the use of consomic strains of rats, we are able to develop congenic strains for our region of interest in only two generations of breeding. Once the region containing the causative gene is small enough, we identify the candidate genes by comparative mapping, DNA sequencing and gene expression.  

Recent Publications:

H. Shao, D.S. Sinasac, L.C. Burrage, C.A. Hodges, P.J. Supelak, M.R. Palmert, C. Moreno, A.W. Cowley Jr, H.J. Jacob. J.H. Nadeau. Analyzing complex traits with congenic strains. Mammalian Genome. 2010 June; 21(5-6):276-86.

A.M.Geurts, C.Moreno. Zinc-finger nucleases: new strategies to target the rat genome. Clin Sci (Lond). 2010 Jul 6;119(8):303-11.

T.Adamovic, D.McAllister, T.Wang, D.Adamovic, J.J.Rowe, C. Moreno, J.Lazar, H.J.Jacob, S.L.Sugg. Identification of Novel Carcinogen-mediated Mammary Tumor Susceptibility Loci in the Rat Using the Chromosome Substitution Technique. Genes, Chromosomes and Cancer. 2010. 2010 Nov;49(11):1035-45.

H.J.Jacob, J.Lazar, M.R.Dwinell, C.Moreno, A.M.Geurts. Gene targeting in the rat: advances and opportunities. Trends Genet. 2010 Dec;26(12):510-8.

M.J.Durand, C.Moreno, A.S.Greene, J.H.Lombard. Impaired relaxation of cerebral arteries in the absence of elevated salt intake in normotensive congenic rats carrying the Dahl salt-sensitive renin gene. Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74.

C.C.O'Meara, J.Lazar, M.Hoffman, C.Moreno, J.H.Jacob HJ. Refined Mapping of the Renal Failure Rf-3 Quantitative Trait Locus. J Am Soc Nephrol. 2011. Mar;22(3):518-25..

C.Moreno, M.Hoffman,T.J.Stodola, D.N.Didier, J.Lazar, A.M.Geurts, P.E.North, H.J.Jacob, A.S.Greene. Creation and characterization of a renin knock out rat. Hypertension. 2011 Mar;57(3):614-9.

C.Moreno , J.M.Williams, L.Lu, M. Liang, J.Lazar , H.J.Jacob, A.W.Cowley Jr, R.J.Roman. Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains. Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5.

Q.Wang, J.Chow, J.Hong, A.F.Smith, C.Moreno, P.Seaby, P.Vrana, K.Miri, J.Tak, E.Chung, G.Mastromonaco, I.Cannigia, S.Varmuza. Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs. BMC Genomics. 2011 Apr 21;12(1):204.

T.J.Stodola, M.M.de Resende, A.Sarkis, D.N.Didier, H.J.Jacob, N.Huebner, O.Hummel, K.Saar, C.Moreno, A.S.Greene. Characterization of the genomic structure and function of regions influencing renin and angiogenesis in the SS rat. Physiol Genomics. 2011 Jul 14;43(13):808-17.

T.A. Stekiel, S.J. Contney, R.J. Roman, C.A.Weber, A. Stadnicka, Z.J. Bosnjak, C. Moreno. Pharmacogenomic Strain Differences in Cardiovascular Sensitivity to Propofol. Anesthesiology. 2011 Dec;115(6):1192-1200. PMID: 22020141


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