FACULTY LIST
 Carol Moreno Quinn, M.D., Ph.D.
Assistant Professor
Phone: (414) 456-4475
Email: quinn@mcw.edu
M.D. Universidad de Murcia, Murcia, Spain, 1995
Ph.D. Universidad de Murcia, Murcia, Spain, 1999
Postdoctoral Fellow Physiology and Genomics, Medical College of Wisconsin, 2004
Complex diseases such as hypertension and renal failure are determined by the interaction of multiple genes with environmental factors. My research interest is focused on identification of the genetic determinants of hypertension and renal disease in rat models of hypertension. Our main strategy is to identify chromosomal regions containing the causative genes through linkage analysis in segregating populations of rats. By the use of consomic strains of rats, we are able to develop congenic strains for our region of interest in only two generations of breeding. Once the region containing the causative gene is small enough, we identify the candidate genes by comparative mapping, DNA sequencing and gene expression.
Recent Publications:
Rangel-Filho A, Sharma M, Datta YH, Moreno C, Roman RJ, Iwamoto Y, Provoost AP, Lazar J, Jacob HJ. RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. J Am Soc Nephrol. 2005 Apr;16(4):852-6.
Moreno C, Pollock DM. Understanding renal and cardiovascular function through physiological genomics. Physiol Genomics. 2004 Jan 15;16(2):178-9.
Moreno C, Dumas P, Kaldunski ML, Tonellato PJ, Greene AS, Roman RJ, Cheng Q, Wang Z, Jacob HJ, Cowley AW Jr. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiol Genomics. 2003 Nov 11;15(3):243-57.
Yu M, Moreno C, Hoagland K, Dahly A, Ditter K, Mistry M and Roman RJ. Antihypertensive effect of glucagon-like peptide in Dahl S rats. J Hypertension. 21:1125-1135, 2003.
Szentivanyi M Jr, Zou A-P, Mattson DL, Soares P, Moreno C, Roman RJ, Cowley AW Jr. Renal medullary nitric oxide deficit of Dahl S rats enhances hypertensive actions of angiotensin II. Am J Physiol Regul Integr Comp Physiol. 283: R266-R272, 2002.
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