FACULTY LIST
 David L. Mattson, Ph.D.
Professor
Phone: (414) 456-8571
Email: dmattson@mcw.edu
B.S. Biology, University of Minnesota-Duluth, 1984
Ph.D. Physiology, Medical College of Wisconsin, 1990
Studies in the Mattson laboratory examine the normal and pathophysiological regulation of renal function and arterial blood pressure. A particular emphasis is placed on the paracrine, autocrine, and hormonal regulation of renal tubular and vascular function. Additional studies are geared toward an understanding of the genetic basis of hypertension and renal disease. The work performed in my laboratory utilizes techniques taken from molecular biology, biochemistry, immunology, and integrative physiology to address the role of the kidney in the regulation of sodium and water homeostasis and arterial pressure. Studies utilize in vitro measurements of mRNA, protein, enzymatic activity, enzyme kinetics, and cell signaling as well as in vivo measurements of hormone levels, blood flow, blood pressure, and other indices of renal/cardiovascular function in anesthetized and conscious rats and mice. Our experimental models include various strains of inbred and genetically manipulated rats and mice.
Recent Publications:
Mattson DL, Meister CJ . Renal Cortical and Medullary Blood Flow Responses to L-NAME and Angiotensin II in Wild-Type, nNOS Null Mutant, and eNOS Null Mutant Mice. Am J Physiol Regul Integr Comp Physiol (Epub June 2005).
Cholewa BC, Mattson DL. Influence of Elevated Renin Substrate on Angiotensin II and Arterial Blood Pressure in Conscious Mice. Exp Physiol. 2005 Jul;90(4) 607-12; [Epub Apr 2005].
Cholewa BC, Meister CJ, Mattson DL. Importance of the renin-angiotensin system in the regulation of arterial blood pressure in conscious mice and rats. Acta Physiol Scand. 2005 Mar;183(3):309-20.
Mattson DL, Meister CJ, Marcelle ML. Dietary protein source determines the degree of hypertension and renal disease in the Dahl salt-sensitive rat. Hypertension. 2005 Apr;45(4):736-41.
Mattson DL, Kunert MP, Roman RJ, Jacob HJ, Cowley AW Jr. Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat. Am J Physiol Renal Physiol. 2005 May;288(5):F1015-22.
Kakoki M, Kim HS, Arendshorst WJ, Mattson DL. L-Arginine uptake affects nitric oxide production and blood flow in the renal medulla. A m J Physiol Regul Integr Comp Physiol. 2004 Dec;287(6):R1478-85.
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