David L. Mattson, Ph.D.
Phone: (414) 955-8571
B.S. Biology, University of Minnesota-Duluth, 1984
Ph.D. Physiology, Medical College of Wisconsin, 1990
Studies in the Mattson laboratory examine the normal and pathophysiological regulation of renal function and arterial blood pressure. A particular emphasis is placed on the paracrine, autocrine, and hormonal regulation of renal tubular and vascular function. Additional studies are geared toward an understanding of the genetic basis of hypertension and renal disease. The work performed in my laboratory utilizes techniques taken from molecular biology, biochemistry, immunology, and integrative physiology to address the role of the kidney in the regulation of sodium and water homeostasis and arterial pressure. Studies utilize in vitro measurements of mRNA, protein, enzymatic activity, enzyme kinetics, and cell signaling as well as in vivo measurements of hormone levels, blood flow, blood pressure, and other indices of renal/cardiovascular function in anesthetized and conscious rats and mice. Our experimental models include various strains of inbred and genetically manipulated rats and mice.
Rajapakse N, and DL Mattson. Role of L-arginine in regulation of nitric oxide bioavailability in health and in hypertension. CEPP 36:249-255, 2009.
Mattson DL. Kidney Function in Mice. Methods in Molecular Biology 573:75-94, 2009.
Pechman KR, C De Miguel, H Lund, EC Leonard, DP Basile, and DL Mattson. Recovery from Renal Ischemia Reperfusion Injury is Associated with Altered Renal Hemodynamics, Blunted Pressure Natriuresis, and Sodium Sensitive Hypertension. Am J Physiol 297:R1358-R1363.
De Miguel C, S Das, H Lund, and DL Mattson. T-lymphocytes mediate hypertension and kidney damage in Dahl salt-sensitive rats. Am J Physiol 298:R1136-R1142, 2010.
Mattson DL. Editorial Focus: Effector Memory T Lymphocytes in Renal Disease. Am J Physiol 299:F1257, 2010.
De Miguel C, H Lund, F Di, and DL Mattson. Infiltrating T lymphocytes in the kidney increase oxidative stress and lead to hypertension and renal disease. Am J Physiol 300:F734-742, 2011.
Pallone TL, A Edwards, and DL Mattson. The Renal Medullary Circulation. Comprehensive Physiology, 2011 (in press).
De Miguel C, H Lund, and DL Mattson. High Dietary Protein Exacerbates Hypertension and Renal Damage in Dahl Salt-Sensitive (SS) Rats by Increasing Infiltrating Immune Cells. Hypertension 57:269-274, 2011.
Rajapakse N, and DL Mattson. Role of L-arginine (L-Arg) uptake mechanisms in angiotensin II (AII)-induced renal vasoconstriction and hypertension. Acta Physiol (in press), 2011.