FACULTY LIST
 Julian H. Lombard, Ph.D.
Professor
Phone: (414) 456-8530
Email: jlombard@mcw.edu
B.A. Biological Sciences, University of Texas-El Paso, 1969
M.S. Zoology, Arizona State University, 1971
Ph.D. Physiology, Medical College of Wisconsin, 1975
Current research in this laboratory utilizes television microscopy, optical Doppler velocity measurements, oxygen microelectrodes, and electrophysiological techniques to investigate the mechanisms by which changes in oxygen availability regulate active tone in microvessels and small resistance arteries. We previously demonstrated that resistance vessels of hypertensive animals exhibit an enhanced constriction in response to elevated PO 2 , and a reduced dilation in response to decreased PO 2 . A major goal of our work is to determine the mechanisms of the altered response of arterioles and small resistance arteries to changes in oxygen availability in hypertension. Another major goal of our laboratory is to identify the mechanisms by which high salt diet leads to impaired vascular function, even in the absence of an elevation in blood pressure. We are also investigating the role of circulating angiotensin II (ANG II) in maintaining normal vascular relaxation mechanisms using novel genetic rat strains [salt sensitive (SS) rats and consomic SS.13 BN rats) that differ in their ability to regulate their renin-angiotensin system and maintain normal circulating ANG II levels. In those studies, restoration of normal regulation of ANG II by substitution of the Brown Norway chromosome 13 (in SS.13 BN consomic rats) restores normal vascular relaxation mechanisms that are lost in SS rats, even when they are on a low salt diet.
Recent Publications:
Drenjancevic-Peric I, Phillips SA, Falck JR, Lombard JH. Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13 BN Rats. Am J Physiol Heart Circ Physiol. 2005; 289:H188-H195.
Drenjancevic-Peric I, Lombard JH. Reduced angiotensin II and oxidative stress contribute to impaired vasodilation in Dahl salt-sensitive rats on low-salt diet. Hypertension. 2005 Apr;45(4):687-91.
Wang J, Roman RJ, Falck JR, de la Cruz L, Lombard JH. Effects of high-salt diet on CYP450-4A ?-hydroxylase expression and active tone in mesenteric resistance arteries. Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1557-65.
Zhu J, Yu M, Friesema J, Huang T, Roman RJ, Lombard JH. Salt-induced ANG II suppression impairs the response of cerebral artery smooth muscle cells to prostacyclin. Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H908-13.
Drenjancevic-Peric I, Greene AS, Kunert MP, Lombard JH. Arteriolar responses to vasodilator stimuli and elevated PO 2 in renin congenic and Dahl salt-sensitive rats. Microcirculation. 2004 Dec;11(8):669-77.
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