FACULTY LIST
 Howard J. Jacob, Ph.D.
Professor
Phone: (414) 456-4887
Email: jacob@mcw.edu
B.S. Biology, Iowa State University, 1983
Ph.D. Pharmacology, University of Iowa, 1989
Using molecular genetics, molecular genetic technologies (e.g. microarrays), and bioinformatics, this laboratory is studying end-organ damage that is caused by hypertension and diabetes mellitus. Our work takes advantage of comparative genomics between human, mouse and rat to implement physiological genomics. Our clinical programs consist of more than 30,000 participants for renal studies, as well as 2,000 participants for myocardial infarction and left ventricular hypertrophy. We have several NIH-funded positional cloning projects underway to identify genes responsible for renal failure and hypertension. In addition, we are funded for two rat genome projects, and expressed sequence tag site (EST) mapping project in which we will map 15,000 ESTs over the next three years, and the Program for Genomic Applications. The PGA enables us to make ANY region of the rat genome congenics within 6 months. As examples, we have developed several new genetic models for diabetes-mellitus-induced renal failure and myocardial ischemia. Collectively, these programs, along with our current microarray of nearly 20,000 genes per array, are enabling us to initiate physiological genomic studies to identify gene function. We are poised to combine the extraordinarily successful sequencing of the human, mouse and rat genomes with physiological studies to identify gene function.
Recent Publications:
Shi Y, Hutchins W, Ogawa H, Chang CC, Pritchard KA Jr, Zhang C, Khampang P, Lazar J, Jacob HJ, Rafiee P, Baker JE. Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. J Mol Cell Cardiol. 2005 Apr;38(4):625-35.
Rangel-Filho A, Sharma M, Datta YH, Moreno C, Roman RJ, Iwamoto Y, Provoost AP, Lazar J, Jacob HJ. RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. J Am Soc Nephrol. 2005 Apr;16(4):852-6.
Fischer M, Broeckel U, Holmer S, Baessler A, Hengstenberg C, Mayer B, Erdmann J, Klein G, Riegger G, Jacob HJ, Schunkert H. Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction. Circulation. 2005 Feb 22;111(7):855-62.
Dwinell MR, Forster HV, Petersen J, Rider A, Kunert MP, Cowley AW Jr, Jacob HJ. Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains. J Appl Physiol. 2005 May;98(5):1630-8.
Mattson DL, Kunert MP, Roman RJ, Jacob HJ, Cowley AW Jr. Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat. Am J Physiol Renal Physiol. 2005 May;288(5):F1015-22.
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