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Daniel A. Beard, Ph.D.
Phone: (414) 456-5752
E-mail: beardda@gmail.com Lab website: http://bbc.mcw.edu/Computation/
B.S. Biomedical Engineering, Boston University, 1993
M.S. Applied Mathematics, University of Washington, 1997
Ph.D. Bioengineering, University of Washington, 1997
Research areas: Computational Biology & Bioinformatics
  Molecular & Cellular Physiology

Research in my laboratory is focused on systems engineering approaches to understanding the operation of physiological systems in health and disease. A recent major effort in our group has been on theoretical and experimental characterization of the thermodynamics, kinetics, and electrophysiology of cardiac mitochondria. We use computational simulation to translate our findings on the function at the organelle level to analyze and interpret in vivo data on cardiac energetics obtained, for example, from 31P-magnetic resonance spectroscopy. Similarly, the development of a mechanistic understanding of the long-term and short-term responses of the myocardium to ischemia and hypoxia requires the development of a model that can predict the effects of modulating expression and activity of mitochondrial and sarcolemmal ion channels on whole-heart mechanical function. This work involves building integrated models of cardiac mechanics, energetics, mitochondrial ion handling, and microvascular oxygen transport. Additional research interests include non-equilibrium thermodynamics in biochemical networks, mass transport and microvascular exchange in physiological systems, and drug metabolism and physiologically-based pharmacokinetics. All of these efforts involve a multi-disciplinary team of mathematicians, engineers, and biologists at the Medical College of Wisconsin.

Recent Publications:

Wu, F, F Yang, and DA Beard. Computer modeling of mitochondrial TCA cycle, oxidative phosphorylation, metabolite transport, and electrophysiology. J Biol Chem. 282:24525-24537, 2007.

Miller, CA and DA Beard. The Effects of Reversibility and Noise on Stochastic Phosphorylation Cycles and Cascades. Biophys J. 95:2183-2192, 2008.

Wu, F, EY Zhang, J Zhang, RJ Bache, and DA Beard. Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischemic hearts. J Physiol. 586:4193-4208, 2008.

Vinnakota, KC, F Wu, MJ Kushmerick, and DA Beard. Multiple ion binding equilibria, reaction kinetics, and thermodynamics in dynamic models of biochemical pathways. Methods in Enzymology. 454:29-68, 2009.

Beard, DA and H Qian. Chemical Biophysics: Quantitative Analysis of Cellular Systems. Cambridge University Press, 2008.

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