FACULTY LIST
 Daniel A. Beard, Ph.D.
Associate Professor
Phone: (414) 456-5752
E-mail: dbeard@mcw.edu Lab website: http://bbc.mcw.edu/Computation/
B.S. Biomedical Engineering, Boston University, 1993
M.S. Applied Mathematics, University of Washington, 1997
Ph.D. Bioengineering, University of Washington, 1997
Research in my group is focused on developing computational models of the transport and biochemical reaction of metabolites and other substances in physiological systems. Our broad goals include development of computational technology for predicting and analyzing the behavior of biological systems, and guiding engineering-based manipulations of biological systems. One current project involves building a multi-scale computational model of cardiac energetics and mechanics, to aid in understanding the pathophysiology of cardiovascular diseases-specifically, the progression of substrate imbalances (hyperglycemia and dislipidemia), hypertension and vascular hyper-reactivity, and insulin resistance and the onset of type II diabetes in the metabolic syndrome. Similarly, the development of a mechanistic understanding of the long-term and short-term responses of the myocardium to ischemia and hypoxia requires the development of a model that can predict the effects of modulating expression and activity of mitochondrial and sarcolemmal ion channels on whole-heart mechanical function. This work involves building integrated models of cardiac mechanics, energetics, mitochondrial ion handling, and microvascular oxygen transport.
Recent Publications:
Beard DA, Bassingthwaighte JB and Greene, AS. Computational modeling of physiological systems. Physiol Genomics 2005 Sep 21; 23(1) 1-3.
Beard DA. A biophysical model of the mitochondrial respiratory system and oxidative phosphorylation. PLoS Comput Biol. 2005 Sep 9;1(4)336 [Epub ahead of print].
Yang F, Qian H, Beard DA. Ab initio prediction of thermodynamically feasible reaction directions from biochemical network stoiciometry. Metab Eng. 2005 Jul;7(4)251-9.
Qian H, Beard DA. Thermodynamics of stoichiometric biochemical networks in living systems far from equilibrium. Biophys Chem. 2005 Apr 22;114(2-3):213-20.
Ejike JC, Arakaki LS, Beard DA, Ciesielski WA, Feigl EO, Schenkman KA. Myocardial oxygenation and adenosine release in isolated guinea pig hearts during changes in contractility. Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2062-7.
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